My Penetrex Pain Relief Cream Review – Is It Any Different?

My Penetrex Pain Relief Cream Review

It’s time for my Penetrex Pain Relief Cream review – a product that is super popular right now.

Well, I will have to be honest

  • Penetrex is a pretty good cream
  • But as a joint remedy – it’s pretty weak

Why? Because it’s a cream. And creams in general don’t do much:

  • they only mask the pain for a few hours (at most)
  • and you have to reapply them 7-8 times a day

So if you want to waste time and money for a minor relief, choose a cream!

But before I give you any alternative, let me tell you everything you need to know about Penetrex – based on my experience, not on general health claims.

Note: This review is based only on my experience with this cream, so it may or may not agree with other reviews you find. I am not trying to praise/criticize the product or its company, I am simply telling my opinion about it.


So Let’s Get To The Review

My Penetrex Pain Relief Cream ReviewFull Name: Pain Relief Cream from Penetrex

Quantity : 2 oz

Best Actual Price: $19.95

Where I Bought It From: Ebay

Designed For: Joint pain in general.

It can work for both osteoarthritis and rheumatoid arthritis – because it doesn’t have any special ingredients.

My Rating: 7.00 / 10.00

Worth The Price?: Not really. It’s better than most creams, but it’s still very weak in terms of relieving pain:

  • You have to reapply it every 2-3 hours – which is really uncomfortable
  • It doesn’t even decrease the pain significantly – even if you apply a thick layer

So it’s not a bad cream at all, but it’s a weak product overall.

In my opinion, it’s definitely not worth $20 (not that any cream does). So I would strongly advise you to try this supplement for the money – there’s a huge difference.



What I Liked

  • Super light (no greasiness) 
  • Soaks in completely after 10 minutes
  • It’s not fragrance free as they said, but it has a very light smell (it can almost go unnoticed)
  • The effect lasts longer than most creams (about 3 hours in my case)
  • Most of its ingredients are natural, classic substances
  • One of the best creams I tried (though pretty weak compared to supplements)


What I Didn’t Like

  • The doses aren’t mentioned anywhere
  • Pretty expensive
  • It only improves the symptoms, not the cause of the pain
  • You need to apply it for a few days before you see any effect
  • It has to be applied 6-7 times a day to keep the pain at a lower level


Is there another product I recommend instead? Yes, but it’s not a cream – it’s a supplement.

Creams are pretty useless on the long term:

  • they don’t repair the joints in any way
  • they only mask the pain for 1-2 hours

Now – Penetrex is a bit better than most creams, but it has the same problems. That’s why I can’t possibly recommend it – it’s uncomfortable and expensive for what it does.

So my advice for you is to try a supplement – turmeric is the best herb for joint pain, so that’s what I recommend.

The following pills are easy to take and they work both on the inside and on the outside:

  • They relieve the pain
  • But also treat the real cause behind

So if you want a long term solution, that’s what I use.





Why I Don’t Recommend Creams (Including Penetrex)

My Penetrex Pain Relief Cream ReviewI never believed in lotions and creams – at least not when it comes to joint pain. Why? I have 5 major reasons:

  • they only treat the symptoms, not the real cause
  • the relief is pretty short (1-2 hours)
  • you have to reapply it up to 10 times a day
  • they’re not very cheap
  • most don’t mention the quantity of ingredients

So creams are basically designed for a local treatment. If you have an injury, they are perfect – they only treat the damaged part.

But joint pain is rarely a local problem.

Most of the times, it’s not just one joint hurting you. This means there’s a problem inside your body  so it’s not a local issue.

That’s why creams don’t do much for pain – in most cases. It does go away for a little way, but it reappears shortly after. 

However, I did a quick research about Penetrex – I read several customer reviews from Amazon.

There were basically 2 types of opinions:

  • positive (about 50%) – some people were praising this cream, but I noticed that most used it for bruises or injuries
  • negative (about 30%) – from what I saw, most people with negative reviews had arthritis or severe pain

There were also some neutral reviews, but I couldn’t draw any conclusion from them.

So because of the reviews (mostly because of the negative ones), I decided to order this cream and give it a try. Here’s the result.



1. Looks & Texture – Different

I’m not an expert in creams and lotions, but I’ve used a few dozens.

So there are a few things I should point out about Penetrex – in terms of look and texture:

1. Non-greasy texture

That’s something pretty rare in actual creams. I could say that about 75% of the joint pain creams I used were super greasy. What do I mean by that?

  • They would slip from my hand within seconds
  • So I had to be very careful when applying them
  • Also, I had to apply a thin layer – because a thicker one could slip

On the other hand, Penetrex is pretty light – so you can add a thicker layer anytime.

2. Gets absorbed pretty fast

Once I apply it on my skin, it takes about 10 minutes for it to soak in completely. You don’t even have to wash it afterwards:

  • it doesn’t leave your skin greasy
  • it simply absorbs completely

That’s something that really surprised me, in the positive way. 

3. Very light smell

According to the label, Penetrex is fragrance free.

Now – I don’t really agree to that, because it has a very light fragrance. I can’t really link it with anything – it’s not natural, but it’s not sweet or spicy either.

So it’s basically not the kind of smell that would bother you – even if you are very sensitive.

But it does exist, so it’s not fragrance free. It’s only very light, so certain people may not feel it immediately.



2. How Fast It Works

My Penetrex Pain Relief Cream Review

I’m going to share with you some things I noticed about this cream and no one told me about. You can take them as a tip, so that you know what to expect from Penetrex:

  • Doesn’t work from the start

When I received the cream and I first tried it out, I didn’t notice any major improvement. Yes, I did have the feeling that my pain decreased a bit, but it might have been just the placebo effect. 

So in the first days, I got absolutely no effect from this cream – despite applying a thick layer every time. 

  • Gets better with time

Believe it or not, this cream started working after about a week of using it constantly. Now, what do I mean by “started working”?

Don’t imagine that it relieved all my pain after a while. It wasn’t this kind of product, believe me. But I did go from a 7 to a 6 on the pain scale. These are some pretty minor changes, but for a cream, it’s not too bad. 

  • Accumulates in the tissue

That’s something particular I noticed about this cream – I could be wrong, but I don’t think I am, at this point. 

I believe that it has to accumulate in the tissue in order to produce an effect. That’s why you don’t feel any change in the first days. I think that it has to penetrate the skin deeply to produce any relief. After all it’s called Penetrex – does it make sense?





3. The Effect – About 3 Hours

My Penetrex Pain Relief Cream Review

So by now, you should know 2 things about Penetrex – compared to other creams:

  • it gets absorbed faster
  • keeps the pain away for longer

But for how long does it work? That’s something essential.

In my case, the best effects came after a week – the pain would go away for almost 3 hours.

That is more than I would have expected, to be honest. But I have an explanation for this:

  • it stars working once it accumulates in the tissue
  • as it adds up, the dose is higher
  • a higher dose leads to a longer effect

So in my opinion, that’s why Penetrex’s effect is longer than in most creams. 

They all work from the first time you apply them, but their effect only lasts for 1-2 hours. 

However, that was only my case. I read different opinions on the internet:

  • Some people said they only needed to apply it twice a day
  • Others would apply it every one hour
  • So I guess it depends from person to person

But in my case, I could apply it 6-7 times a day and my pain wouldn’t increase during this time. 



4. The Real Ingredients

Just like any cream, Penetrex’s ingredients aren’t clearly mentioned.


The label puts together active and inactive ingredients – so if you’re not familiar with joint ingredients, it’s hard to tell what it contains.

My Penetrex Pain Relief Cream Review – Is It Any Different?

So let me do this for you – here are the most important substances from Penetrex:

Now, these are just the main ones. There are so many active ingredients that I couldn’t possibly spell them all out here.

Besides these 6, there are some essential oils like mint and camphor.

But there’s one major problem:

  • there’s no dose for any ingredient

So you can’t tell how much glucosamine or MSM this cream contains. In my opinion, that’s a big downside because the producers aren’t completely transparent. 

They may add 0.001 mg of glucosamine, which is totally insignificant – and still write glucosamine on the ingredient list.

See, that’s the trick when you don’t have the clear dose. So that’s why I don’t like Penetrex from this point of view.



5. Doesn’t Relieve The Cause Of Pain

There’s a tricky affirmation that I found in the description of this product: “Formulated to address the root of the problem”.

Now, I have to be honest once again and tell you that this thing isn’t really possible.

I’m not talking only about Penetrex – I’m talking about any other cream or lotion.

Here’s why:

  • it only masks the pain
  • a few percent of the ingredients get inside the joints
  • it doesn’t literally treat the joints

In fact, there are very few creams that can do more than masking the pain. That’s why I don’t recommend creams in general – instead of supplements or medicines.

So honestly speaking, don’t make huge expectations from this cream:

  • It does relieve some of the pain
  • But it doesn’t take it away completely. Or permanently

If you don’t know much about joint pain – you will probably think that it’s extremely good.

After all, your pain decreases visibly. 

But if you stop using it, does it stay decreased? I don’t think so, because it doesn’t treat the cause, it treats the symptoms.





My Verdict – Is It Worth Buying? 

Short answer: Not really. It’s not a scam or a fake product, because it does work – so you should feel an improvement normally.

But it only masks the pain, instead of improving it.

My Penetrex Pain Relief Cream Review

How do I know?:

  • Stop using it tomorrow
  • And your pain will come back as strong as before

So it didn’t treat your joints in any way, not even partially.

It might be great for a minor injury – but for a chronic pain or condition, it doesn’t do anything major.

Would I buy it again?: Definitely not, even though it’s not the worst cream ever. 

Here are the strong arguments I have against it (and creams in general):

  • only works on the short term
  • you have to reapply it 6-7 times a day (if you use another cream, up to 10 times/day)
  • didn’t relieve my pain with more than 1 number
  • pretty expensive for what it does ($20)

So I would definitely not pay $20 on it again – because I don’t think it’s worth it.

If you want my honest opinion, no cream is worth it:

  • I never experienced any major relief from a cream
  • That even though most are pretty pricey (over $20)

So I wouldn’t really advise you to treat your joint pain with creams.

Penetrex is among the few creams that I can’t strongly criticize. And even so, it’s not worth it.

So if you really want something that works – I recommend you to take a look at natural supplements. That’s what treats the cause of your pain instead of masking it.  

Heather Pharm.D.

Heather Tracy Foley is a Pharmacy graduate, Blogger and Author with a vast experience in health sciences. She has a particular interest in joint pain and rheumatology and spent several years studying health problems. You can find her on Pinterest or via email.

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25 Responses

  1. Dianne says:

    Hi. I was looking for a product for my partner, who recently started having pain in his hands. I wanted something natural so I spent a lot of time on Amazon and saw Penetrex was one of their top recommendations.

    But thanks for this review, it opened my eyes. I checked out some pictures of the label and you’re right. It numbs the painful area and that’s how it relieves the pain. It doesn’t do anything else.

    So you’re right once again, it doesn’t treat the pain in any way. That kind of made me change my mind and buy something else for him.

    Is there any cream that you liked? I mean, one that is worth the money and doesn’t only numb the painful spot. If there’s any, I’d like to check it out. My partner doesn’t like taking pills.

  2. Heather says:

    Hello Dianne. 

    Unfortunately, most creams only numb the area. That’s how they’re created, for a local action only. 

    Just a small part of them gets inside the body, so you would need a huge dose for a better effect. 

    Unfortunately, I don’t think there’s any cream that can really treat the joints. I can recommend you one from Corganics, which is probably my favorite cream:

    – it works faster than most

    – its effect lasts a bit longer, so you need do apply it less often

    But it also numbs the area. So if you stop using it, the pain will come back.

    I understand that your partner doesn’t like swallowing pills – but in my opinion, they’re the best choice. 

    But well, he knows better. If his hand pain is minor, then creams might work good enough for him (because he won’t have to apply them constantly). Does he know the cause or it’s just a pain that comes and goes?

  3. Johanna Christiansen says:

    Hi, thanks for all this honest info. I didn’t see a lot of personal reviews on the Internet and that’s what I was looking for.

    I wanted to buy this cream for my husband that deals with joint pain all the time. He doesn’t have any arthritis or anything, he just has this pain.

    I found many good reviews on Penetrex and that’s why I thought about buying it. But you say it only masks the pain, and that makes sense to me.

    So do you think I should get my husband a supplement instead? Or he could start with the cream and see if it helps?

  4. Heather says:

    Hello Johanna.

    Penetrex isn’t bad at all – in fact for a cream, it’s pretty good. The problem is that creams in general don’t help a lot, that’s why I don’t recommend them too much.

    Regarding your question, it depends what kind of joint pain has your husband? Is just one part of his body aching? Or does he have joint pain in several parts? 

    If he doesn’t have just one type of joint pain – then I definitely recommend a supplement. Pills work for the whole body, so it’s much easier. 

    On the other hand, if it’s just one part of his body hurting – he could try with a cream. But the downside here is that he would have to apply it several times a day. 

    So if he’s comfortable with that, he can try Penetrex and see how it goes.

    Otherwise he can start directly with a supplement and he should experience some relief straight away.

    As you didn’t mention what kind of pain he has, I recommend you this list I mad on the best supplements for joint pain. 

    It’s focused on knee pain, but that doesn’t really matter. All of those products are good for any kind of joint pain, not just knee pain.

    If you can give me more details about your husband’s pain, maybe I could help more:

    – When did it begin?

    – How strong is it (on a scale from 1 to 10, 10 being the worst)?

    – Is there any swelling?

  5. Kevin says:

    Thank you so much for your honest review about Penetrex. 

    My mother has suffered very badly from arthritis over the past few years and is often looking for alternative relief but your review has actually reinforced what we have discovered that treating the root cause is a much better option than looking just for temporary pain relief. 

    We have had great success by changing her diet to a plant based one and incorporating organic turmeric and ginger whenever possible. 

    She also takes a Vitamin C and Rosehip supplement as well as glucosamine that all seem to work well for her. 

    I would be interested to see if the Turmeric Plus capsules are available here in the UK as that could also be an option for her. 

    Of course at times a pain relief is required but she dislikes taking your typical over the counter tablets. Is there a natural pain relief that you would recommend? Thanks again for a helpful and honest review.

  6. Heather says:

    Hello Kevin. I would need to know one thing that you didn’t mention: what kind of arthritis does your mother have?

    From your description I believe she has osteoarthritis but I can’t tell for sure. This forms appears when you grow older, so that’s what I think she has.

    Yes, healthy foods help a lot in this condition – I experienced that myself. So tell her to continue with the diet, first of all.

    Secondly, if she has osteoarthritis – turmeric isn’t going to help her much. Let me explain:

    In OA, it’s the loss of cartilage that causes problems. There’s little inflammation – so the pain, stiffness and loss of flexibility are all caused by cartilage loss.

    Now – turmeric is a natural anti-inflammatory. If your mother has osteoarthritis, she has little inflammation. Turmeric helps with that – and that’s the reason why she feels better. But it doesn’t do anything for the loss of cartilage (which is the real cause of the problem).

    And that’s what glucosamine is for. This substance is the best at re-building cartilages – which is what your mother needs.

    So I wouldn’t really recommend her Turmeric Plus, but rather a supplement that re-builds cartilages and also has some turmeric inside.

    Now, my top recommendation would probably be ProJoint Plus. But you said you lived in the UK, and I don’t think they ship there. 

    So I would recommend you a product that is a bit more expensive, but it does the same thing as ProJoint Plus. You can read my whole review here. 

    As I said, it’s a bit more pricey so if you think it’s too expensive for you – just get back to me and I will try to find something else instead.

    And there’s one more thing I want to tell you – about glucosamine:

    No matter what supplement you choose, make sure it contains glucosamine sulfate, not HCl. That’s something that can make a difference, I say that from experience.

  7. zake says:

    I know creams are not the best option for pain, but rather for bruises and skin infections. How can I convince my grandpa to take turmeric pills?

    He has arthritis and swollen joints and is always in pain, but he refuses any kind of extra pills.

    He uses Penetrex for a while now and says he feels better, but I see him struggle with pain even though he doesn’t want to admit it. He has bad arthritis so maybe that’s why it doesn’t work for him. I’m sure turmeric would help, but he’s just so stubborn.

  8. Heather says:

    Hi Zake, he really is stubborn 🙂

    If he has bad arthritis – turmeric is one of the few natural things that could really help him. Penetrex probably doesn’t do much – he’s just too stubborn to admit he was wrong.

    From your description, I believe he has some inflammation problems, so turmeric is my top recommendation.

    I just thought about a plan and I think it should work:

    – take the powder from the pills and add it either in his food, juice or tea
    – tell him you added an extra spice or anything like that
    – make him eat or drink it everyday for at least a week

    The only problem I can see is absorption. I know the capsule protects the turmeric powder and only releases it in the right place. So maybe the powder won’t get absorbed completely like this.

    But at least it should get absorbed partially. So he should feel an improvement at one point. Please do this and let me know how your grandfather feels.

    Regarding the supplement you use, here’s my best of list. But I advise you to stay away from the expensive ones, because what you’re going to do is some kind of experiment.

    Hope this helps.

  9. Stacie says:

    I have tried so many topical creams and you are right, they just don’t go deep enough to stop the pain and feel complete comfort. 

    I have a bad form of arthritis, I live in a dry climate just to avoid living in pain, when a storm comes in it still affects me, my knees and shoulders hurt so bad, and then a nerve in my back pinches and I am done!

    I used to take Ibuprofen by the handful, I realized that was creating more issues than I wanted as well. I now use a combination of Turmeric, Curcumin, and Ginger Root and this has been working great! 

    I found a lot of great information that confirms the supplement choices I prefer.Thank you for such a wonderful and honest review.


  10. Heather says:

    Hi Stacie, I know exactly what you’re saying. I also live in a dry climate just to prevent my RA from getting worse – and it does help.

    But I understand the rain problem you have – it happens to me as well. My flareups increase once there’s more humidity.

    I’m glad you agree with me and unfortunately, no cream is going to help people like us with arthritis. Either it’s Penetrex or a $50 one, it’s not going to help on the long term.

    It’s great to hear you found the solution for your pain. It took me a while, but I got there too. Now I’m trying to help other people get relief too.

    Thanks for your kind words.

  11. Niesha says:

    Does this get hot when you apply it? How does that work? 

    My mother had a cream similar to this I think it got hot when applied she said it had a weird smell too. 

    I don’t know maybe it was something different but she said it definitely numb the pain for a while. Is this on Amazon? I wanna try it for my lower back. Or would you recommend a supplement instead?

    I’ve been having crazy weird pain there and nothing seems to be working.

  12. Heather says:

    Hey there Niesha.

    That cream that your mom had was probably based on red pepper. It’s the only thing I know that works by heating up the painful area. This also explains the weird smell. And yeah, pepper extract is pretty used for joint and back pain.

    Penetrex doesn’t have any pepper extract, so it doesn’t get hot. It’s actually based on Arnica and some essential oils. They also work by numbing the area, so that you don’t feel the pain anymore.

    Regarding your lower back pain, I assume you don’t know the cause behind (since you didn’t mention it).

    But most pains from that area are caused by inflammation – whether it’s your SI joint or any other one affected.

    I think you should straight with a supplement – and I would recommend you turmeric to get the best effect. It decreases inflammation better than anything and it’s very safe.

    Now – let me ask you. Have you tried any other creams? 

    If you didn’t and you would prefer a cream instead of a supplement – then you could try Penetrex. 

    But my advice is to start directly with the turmeric supplement, because it has a higher rate of success. And it’s also cheaper, compared to the cream. But it’s your decision and choose what suits you best.

  13. Javier Weffer says:

    I suffer from Kienbock’s disease in my right wrist but for the last few years I haven’t had pain. But during this season the cold weather brings back all these old pains and normally the pain goes to the next joint, meaning my elbow. And like you said Penetrex and other creams do not work but my pain is not chronic anymore since I retired now (I used to be a tennis pro). What kind of cream will you recommend for seasonal join pain?

  14. Heather says:

    Hi Javier, from what I understand your pain only comes up during the cold season. It’s probably of humidity and lower temperatures.

    I would normally recommend turmeric, but I don’t think in’s the case for you. There’s probably no inflammation and definitely no arthritis.

    But since Penetrex and other creams didn’t help you, I would recommend turmeric powder alone (not as supplements). 

    It’s much weaker than the supplements, because it doesn’t contain the strongest compounds (the extracts). But for you, it should be enough. 

    You should use the powder in foods, beverages, soups or anything. 

    You can check out this article if you want more suggestions – it’s focused on knee pain, but you can use these ideas for any kind of pain.

    Try this and let me know how it goes. If you don’t see any positive results, I will give you a second alternative. 

  15. fyre says:

    Like you, I’ve tried a lot of creams in my day, especially for my hands that have had chronic (the doctors say arthritic) pain since I was a kid.  When I got my herbalist certification I realized quickly that besides my yoga, qi gong & Tai Chi exercises, I was really only treating the symptoms with various NSAIDS and not the cause!

    Again, like you Heather, I have never found a decent cream.  

    It was impossible for me not to read your highest recommendation and I concur wholeheartedly.  Tumeric has changed my world dramatically.  I haven’t tried the particular brand you use but, I have heard only positive feedback from friends who use it regularly.  Your brand has that key ingredient Bioperine (aka: the only patented extract of black pepper fruits) without it the Tumeric’s curcumin absorption rate is too low to see any benefits.

    Apologies, for rambling.  I just get excited when I see a pharmacist or, others in the medical field, helping people treat the CAUSE and, not just the symptoms of chronic dis-ease.  Black pepper (fresh ground & Bioprerine extract) also, helps with the absorption of other nutrients as well.  It’s a win win all around great supplement & healer in my book! 


  16. Heather says:

    Hey there, thanks for your comment.

    It’s sad to hear you also got disappointed by creams. But that’s the truth, they can’t do a lot for any joint problem.

    You have such an impressive list of things you tried! I’m familiar with Yoga, I also tried it too but it didn’t bring me more than a pshychical relief. I only tried it for a month, that’s true.

    Regarding turmeric, I know there are some other good brands on the market. I just react best to the one I recommend (and I got some great feedback from readers that tried it as well). Another reason why I recommend it is because it’s cheaper than most, which is really important for me.

    But it doesn’t really matter what brand you’re using – as long as it works for you. You pointed out right – bioperine is essential, I wouldn’t even try again a supplement without it.

    Thanks for letting me know your opinion.

  17. Rick Nellison says:

    Hey Heather

    I was looking for cream which can remove the joint knee pain. Pentrex might just do for me. I’ve seen you recommend supplements rather than creams, and after your explanation I really understand why.

    But my joint pain isn’t very severe and I don’t have arthritis, I simply hurt my knee playing football last week and my joint has been hurting ever since. Even my doctor said it was nothing serious, but he didn’t prescribe anything and I’m still in a bit of pain. Getting better, though. 

    Do you think this Penetrex cream would be enough for me? I’m not into swallowing pills, that’s why I would rather use a cream. Thanks

  18. Heather says:

    Hello Rick. Based on your description, your problem is probably pretty minor, just as you say. 

    I don’t think there’s more than a tendinitis or a sprain – but these problems usually go away on its own if you rest enough. Especially if you’re young and healthy, there’s no need to worry too much.

    So basically, I think Penetrex could be enough for you. As there’s no arthritis behind your pain, you don’t really need a pill. An external relief is enough, and that’s what creams are for.

    So you’re really lucky – there’s no need for supplements.

    Now – in terms of creams, I don’t have a personal favorite. There’s one that I really liked, but it might more expensive after the shipping expenses (I don’t know where you live). 

    So Penetrex is okay as a price overall. There’s also Biofreeze, which also works and is considerably cheaper – but it kind of numbs the area where you apply it, which is why I don’t really like it.

    But as a price, it’s cheaper. Here’s a comparison between Penetrex and Biofreeze, if you want to see them one by one.

    So if you’re okay with Penetrex’s price, go for it. If you want something even cheaper, try Biofreeze instead. 

    Either creams should be good enough for your problem, so I don’t recommend one more than the other.

    But if your pain doesn’t disappear in several weeks, get back to your doctor again. It might be something more serious in that case. 

    Hope this helps.

  19. Tricia says:

    Thanks for reviewing Penetrex. 

    This is just based on my knowledge from the variety of experiences I’ve had and things I’ve learned… I’m not quite sure why they call it a pain reliever when Arnica, MSM, glucosamine and boswellia are used more for healing than pain relief. If it’s used for a long period of time I can see some benefit but for quick relief, not so much.

    I agree though, that in order to get real relief you need to go after the ROOT cause. So many people jump to quick bandaid solutions expecting the problem to be fixed and in the end, they just don’t work.

    I will listen to your advice and get a supplement instead of Penetrex.

  20. Heather says:

    Hello Tricia, it’s great to see that you understand why creams aren’t that beneficial for joint pain.

    And you’re right – most of the ingredients from Penetrex work better on the long term than for a fast relief. I’m speaking mostly about Glucosamine, MSM, Boswellia.

    Arnica is rather a pain reliever, but it doesn’t work instantly (as menthol, camphor, etc.).

    But other than these – there’s no major ingredient. So that’s probably why Penetrex needs a few days to work, unlike most creams.

    Anyway – I definitely recommend you to get a supplement instead of it.

    They have much better results on the long term. And in my opinion, they’re more comfortable to use (you don’t have to reapply them every 2-3 hours, as with creams).

    I don’t know what exact problem you have – but if it’s arthritis or joint pain, here are my top recommendations.

  21. Barb says:

    Thanks for reviewing Penetrex, I was looking for a potent joint remedy for my father in law. He has always had many problems regarding arthritis. Some stuff works better, other works less, but he is always in quite a bit of pain in his joints.

    Your article was an eye opener to me, because he prefer to uses lotions and creams. But they actually only treat the pain, not the root, which is why the pain always returns. That really makes sense, thanks for putting it so straight.

    I don’t know what kind of arthritis he had, but probably osteoarthritis, what do you think? He’s over 80 and it started about 20 years ago I think. So in this case, what supplement would you recommend? I will convince him to give another try to non-prescribed medicines so I would need some serious advice.

  22. Heather says:

    Hello Barb, it’s great to hear you understood the difference between a cream and a supplement.

    Basically – creams will never do what pills can do. They only work on the outside, while pills work from the inside on the outside. That really makes sense and it explains why the pain always comes back after using a cream – whether it’s Penetrex or any other.

    From your description, your father in law surely has osteoarthritis.

    This condition appears due to aging (mostly) – so it fits its case perfectly. I will also add that he probably has some stiffness as well and has a hard time moving around, right? These are typical symptoms of OA as well.

    Now – I would recommend it a supplement with glucosamine and chondroitin.

    Basically, osteoarthritis appears due to cartilage damage. That’s what causes the pain, actually. It’s not the joints that are in a bad shape, it’s their cartilages. So since it’s bone to bone, there’s a lot of friction and pain.

    Thing is – glucosamine and chondroitin can rebuild damaged cartilages. Actually, they’re the best substances at that.

    That’s why I really recommend them for OA.

    So basically – your father in law needs a supplement with glucosamine, chondroitin and other additional substances (like MSM, collagen, Boswellia, etc.).

    My top recommendation is ProJoint Plus, because it’s the cheapest product that worked really well for me. 

    But I advise you to check out this list on the best products for OA and take a decision. I don’t know your budget, that’s why I can’t recommend you something for sure.

    But if you don’t want to spend a lot of money, ProJoint Plus would be my pick.

    Also, there are some other things your father in law might try, besides supplements. Following a healthy diet surely helps, and so do some natural remedies

    If you convince him to give them a try, he will surely feel better in a few months.

    In case you need any other advice, please let me know. Hope this helps.

  23. sharon says:

    for me, i’ve tried turmeric w/ pepper for assimilation, advil etc., biofreeze and many others – none worked.
    i have 2 knees w/ arthritis. it’s bone on bone and i qualify for knee replacement and get cortisone shots every 9 months. so it’s painful enough to cause a limp often. i am 51 and am chicken to get surgery and feel l’m too young to have it yet anyway. tried many creams w/o any relief. with so many great reviews i took a chance on penetrex 2 years ago and it has been a godsend. i have to live frugally so only use it 1/day and it still gets me back on my feet in 15 min. lasts about 4 hours w/ my 1 application. maybe doesn’t work for everyone but you really should try to see if it helps you.

  24. sharon says:

    * should have added i tried glucosamine/choindrotin types without any reduction in pain either.

  25. Heather Pharm.D. says:

    Hi Sharon, your experience with Penetrex is definitely amazing, thanks a lot for your feedback. I’m honestly surprised to hear you saw no reduction with turmeric, glucosamine + chondroitin, creams like Biofreeze and other products – and stil, you had great results with Penetrex. I personally was quite about the opposite. But you’re right, we are all so different so what works for me might not work for you as well.

    I’m glad to hear you don’t have to go for a knee replacement at this point, due to Penetrex. So if this cream is so helpful, all I can tell you is to keep using it. Maybe it’s the best thing you can have right now. Thanks a lot for sharing your experience with it.

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