My Flexiseq Gel Review – Is It Really Good?

My Flexiseq Gel Review - Is It Really Good?

It’s time for my Flexiseq Gel review – because I heard so many praises about this product. 

In fact – it’s so famous because it’s different:

  • has a unique formula
  • not based on pain relieving substances
  • uses a new technology

So Flexiseq doesn’t have anything in common with most pain relieving creams. Except the fact that it’s a gel.

But is it any good? Does it work for real – or it’s just this hype around it? 

Well – I tried out Flexiseq myself, so I will show you below what’s the truth behind it.

Note: This review is based on my experience + opinion on Flexiseq.


So Let’s Get To The Review

Full Name: Flexiseq

My Flexiseq Gel Review - Is It Really Good?Versions: There are 2 different forms:

  • Flexiseq Osteoarthritis (designed for cartilage problems)
  • Flexiseq Active (lighter formula, so it’s better for milder pain)

However – they both do about the same thing, so you can use any.

Best Actual Price: Around $18 

Where To Buy It From: Amazon or Ebay

If you live in UK, you can also find it on the official website – but it’s a lot pricier (compared to Amazon UK).

Designed For: Cartilage/Joint pain and stiffness. It claims to:

  • lubricate and protect the joints
  • relieve pain and stiffness
  • improve joint function

However – it’s just a topical get, so I doubt it could actually treat the joints (only pills can do that).

My Rating: 8 out of 10 It’s a good product, but too expensive for me.

Worth Buying?: Only if you afford it. I’m personally satisfied with it:

  • original formula
  • works pretty well for pain/flexibility
  • many positive reviews

The only problem is that it’s a topical reliever – and these products can’t treat arthritis alone.

So I mostly recommend it if you also use a quality supplement additionally.


What I Liked About It

  • Unique formula/mechanism of action
  • Doesn’t contain any active ingredients
  • No smell or color
  • You only need to apply it 2 times per day
  • Works really well for pain, inflammation and mobility
  • Many positive reviews
  • You can find it in several retailers


What I Didn’t Like About It

  • Leaves your skin sticky
  • The effect only lasts for 4-5 hours (in my case)
  • Doesn’t treat the real cause behind the pain
  • Very little quantity per tube (1.7 oz)
  • Expensive overall



What is Flexiseq Gel? A Quick Overview

Shortly – it’s a topical product with an unique formula:

  1. My Flexiseq Gel Review - Is It Really Good?Doesn’t have any active ingredient.
  2. Works using a SEQ technology.
  3. Has no potential side effects.

Now – how exactly does it work, since it has no active ingredients? What is that “SEQ technology”?

Basically, it’s an original treatment option that lubricates the joints:

  • contains some particles called Sequessomes
  • they are meant to nourish/lubricate the joints
  • in this way, they create a lubricating layer on the cartilages
  • that’s how the pain goes away pretty fast

Does it sound too good to be true?

Well – the downside is that this lubricating layer doesn’t last forever. 

In fact – it’s only temporary (a few hours). So Flexiseq isn’t a real treatment – just a temporary pain reliever.

So now that you know the basic things about it, it’s time to analyze it closer.


#1 – Ingredients (9 out of 10)

That’s what makes Flexiseq so special:

  1. Doesn’t contain any common ingredients.
  2. Works in a physical way.
  3. Free of any side effects.

So basically – there are no ingredients in this gel. That’s why I can’t analyze anything here (as I usually do).

However, let’s take a quick look at Flexiseq’s formula. 

1. The Formula

As I said, Flexiseq doesn’t work like most pain relieving creams. Instead:

  • it’s made of oily droplets called “Sequessome” 
  • these droplets penetrate the skin to the joints
  • once they get there, they start building a lubricating layer around cartilage
  • that’s how flexibility improves withing minutes

So Flexiseq’s formula is surely unique. As it claims – it works in a mechanical way (not medical).

I personally don’t know any cream/gel with these proprieties, so Flexiseq is surely amazing.

2. Real Evidence

A great thing about Flexiseq is that it has some studies behind. 

Now – I couldn’t find many studies on Flexiseq itself, but I found some on the type of formula it uses (ketoprofen-free gel):

  • most results were positive [1]
  • the formula has the same effect as NSAIDs [2]

Besides, Flexiseq has a clinical trial going on at this point. [3]

So to me – that’s the best evidence that this formula isn’t a scam.

Very few joint products have studies behind and they’re still effective. So a product that has clinical evidence should be even more effective.


Flexiseq may have a different formula – but it’s surely a good one.

So compared to most arthritis creams, it surely looks way more promising.


 #2 – Smell & Texture (8 out of 10)

Unlike most creams and gels, Flexiseq looks pretty good at this chapter too.

1. Smell

As I said – this product doesn’t contain any common ingredient (like menthol, camphor, etc.).

For this reason, it’s great if you’re sensitive to intense scents:

  • doesn’t smell almost at all
  • you can at most perceive a light fresh scent

However – I personally couldn’t feel any smell. 

So if you’re looking for a topical product that doesn’t smell, Flexiseq is just perfect.

2. Texture

That’s not my favorite part about this gel:

  • only starts working after it dries out
  • it takes a long time until it penetrates the skin
  • this can take about 20-30 minutes
  • leaves the skin sticky afterwards

So even though it’s easy to apply, it takes a lot more time to work (compared to many creams). 

That’s the biggest problem in terms of texture, if you ask me.

But other than that – Flexiseq looks pretty well. You only need to be patient while using it.


#3 – How To Apply It (9 out of 10)

Unlike most creams, Flexiseq has some clear instructions about how you should use it:

  1. My Flexiseq Gel Review - Is It Really Good?Apply it twice daily (morning + evening).
  2. Depending on the area where you apply it, use an appropriate quantity.
  3. Spread the gel on the painful area.
  4. Let it dry for about 10 minutes (I say more).
  5. If it’s your knee hurting, apply it on the back and sides.

I also like that they recommend the quantity you need to use:

  • for knee, shoulders, hips: as long as your index finger
  • for ankle, wrists, fingers: as long as half your index finger

So in my opinion – Flexiseq is quite easy to use.

The only downside is that it takes a while until it soaks in completely (more than 10 minutes – at least in my case).

Also, washing your hands is a must – because it leaves your skin very sticky.


#4 – My Results (8 out of 10)

First of all – Flexiseq worked really well for a cream. 

However – as it’s a topical reliever, I don’t consider it a long term treatment for joint pain (I will explain below why).

1. My Background

I was suffering from both rheumatoid and osteoarthritis (a secondary complication):

  • my RA pain was the worst (hands + elbows)
  • it was sometimes unbearable during rainy days
  • I also had morning stiffness for about 1 hour daily
  • I only had OA in my knees
  • the pain wasn’t so bad, but I had very little flexibility

So basically – I had several types of pain.

If Flexiseq could relieve the pain, I was the best person to test it out.

I was convinced it normally helps – but would it also help my severe RA pain? It was time to find out.

2. How It Worked

As I said, I was quite satisfied with Flexiseq’s effect (for a cream, I mean):

  1. It took about 30 minutes until it started working. 
  2. My pain would decrease considerably everywhere I applied the gel.
  3. In my hands, it would go from a 6 to about a 3.
  4. In my knees, it would decrease almost completely (from a 2 to 0).
  5. My knee flexibility also improved.
  6. However, my stiffness would still last about 30-40 minutes every morning.
  7. Besides, Flexiseq’s effect would only last about 4 hours.
  8. Afterwards, all the symptoms returned in the same intensity.

My Flexiseq Gel Review - Is It Really Good?

So basically – Flexiseq was really effective in terms of relieving pain/stiffness.

But the problem is that its effect was very short. In my case, it would never last more than 5 hours.

Sure enough, you can apply the gel again. 

But the symptoms will always return. So that’s a major sign that Flexiseq is only a temporary reliever – not a long term treatment.

That’s the #1 reason why I wouldn’t recommend it alone.

If you want a real remedy, use a supplement first. You can also add Flexiseq – but the supplement should be a must (in my opinion).


Flexiseq does relieve the pain – and it does it pretty well.

However, it’s still a topical reliever. And that means it only works on the short term – which isn’t very useful for arthritis. [4]

So if you have a chronic pain, I recommend using a supplement – and only additionally, a pain relieving gel.

That if you want to treat the cause of the pain (not just mask the symptoms).



#5 – Other Opinions (7 out of 10)

I tried to check out some other reviews on Flexiseq – so that I could judge fairly.

And luckily, I could find plenty of real opinions (as far as I could tell).

Note: I only considered authentic reviews, not general ones.

1. What People Say

I will mention the most common praises/complaints I found about Flexiseq:

  1. Some people say it works from the first try.
  2. Other praise it for having no smell and side effects.
  3. A few say it made miracles for their stiff joints.
  4. Some other claim it worked, but it’s too expensive.
  5. Others say it didn’t work better than most creams.
  6. Some others say it works, but the quantity is very little.

Basically – my conclusion after reading these reviews is that Flexiseq works for more than 50% of the customers.

However, it runs out very fast (considering it’s less than 2 oz per bottle).

2. Biggest Complaints

Believe it or not – it wasn’t the effect.

As I said, most customers were satisfied with how Flexiseq worked. Obviously – not all, but a decent per cent.

However, most complaints were related to another aspect – quantity:

  1. Many people said it’s extremely little.
  2. Other claimed it would finish after using it 5 times.
  3. Some others said it was really pricey for this quantity.

To be honest – I pretty much agree.

My own bottle also ran out pretty fast – in less than 1 month, if I remember well.

So if you want to use Flexiseq for more than 1 month, I advise you to buy 2 tubes from the start.


#6 – Price (6 out of 10)

That’s probably the biggest downside of Flexiseq – it’s too expensive to afford on the long term.

I’m speaking for myself, but many people probably agree with me.

1. The Exact Price

At first sight – you might say that Flexiseq is actually affordable:

  • costs about $18 per tube
  • the price can be even lower in some retailers (about $15)

However – the secret is to look at its quantity.

You’re actually paying $18 for 50 g – which is less than 2 oz (1.7 to be exact).

Well, for this quantity, Flexiseq is indeed pricey.

I’m not claiming it’s a weak or ineffective product – on the contrary. But paying $18 for less than 2 oz seems way too much for me.

If you follow the instructions from the label, that quantity won’t be enough for 1 month.

So I personally couldn’t afford buying it constantly.

2. Competitors’ Price

I will try to compare Flexiseq with other pain relieving creams I tried:

  1. Flexiseq costs about $18 for 1.7 oz.
  2. Biofreeze costs around $12 for 4 oz.
  3. Australian Dream costs abour $29 for 4 oz.
  4. Blue Emu costs about $15 for 4 oz.
  5. Flexdermal costs around $30 for 4 oz.
  6. Joint Flex costs less than $16 for 4 oz.

Now – not all of these creams have amazing prices.

But all of them are more or less cheaper than Flexiseq (in terms of price/quantity).

So Flexiseq is surely not an affordable product.

That’s why I personally would think twice about buying it. (Especially when supplements have a much better effect and costs less).


Flexiseq is one of the priciest creams I personally tried (due to its low quantity).

So for these money – I would buy a supplement instead.

It has a much better effect and it treats both the cause and the problem (unlike topical products).

So I think it’s a lot more worth it than a temporary cream/gel.



#7 – Where To Find It (9 out of 10)

Fortunately, Flexiseq is available in several retailers. 

My Flexiseq Gel Review - Is It Really Good?Normally, it should only be available in the UK – because that’s where the official website ships to (ONLY).

But thanks you Amazon (and Ebay), you can now get it in the US as well.

So here are the top 3 retailers you can get Flexiseq from:

  1. Amazon
  2. Ebay
  3. The official website (only if you’re from UK)

Out of these – my top choice would be Amazon:

  • free shipping in most cases
  • best price overall
  • products can be returned (in case there’s any problem with the package)

Ebay does have some lower prices – but it’s way more dangerous. Plus, you might have to pay the shipping fees.

Regarding the official website, I wouldn’t recommend it even if you live in the UK.

Flexiseq’s prices are far higher than on Amazon UK – so there’s no point paying more, if you ask me.

Therefore – I consider Amazon as the best choice for Flexiseq right now.


#8 – FAQs

Here I will try to answer the main questions you might have about Flexiseq.

Note: I might repeat something I already said, but it’s easier to spot here.

1. How often do you need to apply it?

According to the label – 2 times per day (morning and evening).

But from what I read, you can also apply it whenever the effect disappears. There’s no risk of overdosing.

2. How long lasts 1 tube?

That depends of how often you use it – there’s no clear dose.

Just keep in mind that 1 tube has 50 g (1.7 oz) – so it won’t last too long.

In my case, it was enough for about 3 weeks (I applied it twice per day).

3. Are there any side effects?

Absolutely not. Flexiseq uses a physical formula, not a medical one.

So since it doesn’t have any active ingredient, it can’t cause any secondary effect.

4. How fast should I notice an effect?

Normally – it should work from the first time you use it.

Just wait about 20-30 minutes until it dries and soaks in completely and then you should feel an improvement in your pain.


#9 – Final Conclusions

Coming up, I will try to sum up my opinion on Flexiseq in 3 ideas.

1. Unique Formula

I don’t know any cream that has the same mechanism as Flexiseq:

  • no active ingredients
  • based on special droplets that lubricate the joints
  • no side effects

So at this chapter, it surely has an advantage.

2. Works Really Good

I tried it out myself and I was very satisfied with the results:

  • works very fast
  • decreases the pain considerably
  • also improves flexibility

Besides, I found many positive reviews about it.

However – Flexiseq’s effect lasts very little (just like most creams do).

That’s why it’s not a proper treatment for arthritis – at least not alone.

3. Very Expensive

Even though it has a great formula, Flexiseq is still extremely pricey:

  • costs about $18 per tube
  • there are only 1.7 oz in each bottle

So it’s not expensive in terms of price. It’s expensive in terms of quantity/price.

That’s why I would think twice before buying it.

Instead of getting a temporary reliever – I would choose a supplement. It treats both the cause and the pain, on the long term.


My Verdict – Is Flexiseq Gel Worth Buying?

Short answer: If you afford it, yes. It’s one of the best topical relievers I tried:

  • My Flexiseq Gel Review - Is It Really Good?unique formula
  • works pretty fast
  • decreases any kind of pain considerably 
  • also effective for mobility

The biggest downside it that it’s extremely expensive for the quantity.

And just like any cream – its effect is only temporary.

So I would surely not recommend it as a lone treatment.

If you have arthritis or chronic pain, taking a supplement should be the #1 choice (out of alternative remedies – your medical treatment should be the very first).

You can also use a cream, but only as an additional treatment:

  • they only hide the pain for a short while
  • afterwards, the symptoms come back
  • the real cause of the pain isn’t treated

So I do recommend Flexiseq, but only if you use an internal product besides.

For this reason – make sure you spend your money wisely and get the best thing for your problem.


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Heather Pharm.D.

Heather Tracy Foley is a Pharmacy graduate, Blogger and Author with a vast experience in health sciences. She has a particular interest in joint pain and rheumatology and spent several years studying health problems. You can find her on Pinterest or via email.

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4 Responses

  1. Lloyd Bennet says:

    Hi, Heather, I really love what Flexiseq does for my wrist joints. I tried many other creams but the effect wasn’t always the desirable one. But I felt better from the first time I used Flexiseq. My wife has knee arthritis and she also experiences relief with this gel. We live in the UK and I know the company is based there, so maybe this is why we find it cheaper. Here it’s indeed a bit pricey, not affordable for everyone. But for people living in the UK or nearby, this gel is a must!

  2. Heather Pharm.D. says:

    Hi Lloyd, thank you for sharing your experience with Flexiseq. It’s great to hear it worked so well for you and your wife. 

    I never checked Flexiseq’s price in UK, but I know it’s produced there. So it makes sense being cheaper.

    But here in the US, it’s not as affordable. It’s surely a good product for pain, but I wouldn’t recommend it as a lone remedy. I mean – it takes away the pain but only for a short while. It doesn’t help the cause inside your joint in any form. That’s why your problem could worsen on the long term, especially as the painful symptom is masked.

    That’s why I recommend to use it always together with a supplement/drug. There are many supplements that work really well for arthritis and don’t cost a fortune. So they work on the inside and Flexiseq does the outside job. They’re a perfect combination.

    Thanks again for letting me know your opinion.

  3. holly says:

    does this product work for osteoarthritis? i heard many positive comments about it so i’m interested.

  4. Heather Pharm.D. says:

    Hi Holly. Flexiseq can be effective in OA pain, but it’s just an outside remedy.

    I mean – it only hides the pain for a couple of hours, but then the pain comes back as strong as before. So basically – if you used it for 3 months continuously, your problem didn’t get any better. Instead, it might worsen – since you’re not treating the cause inside.

    That’s why I recommend using a supplement as a #1 choice. Here’s a list of the best OA supplements I know – so you will surely find something that suits your budget there. Shortly, you need a product based on glucosamine sulfate and chondroitin (the best substances for OA).

    You can also use Flexiseq additionally, but not alone. So the supplement/drug is a must and any cream or gel can be used additionally (but not alone). That if you really want to keep your condition under control in a correct manner.

    Hope this helps.

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